Nanoformulation of the PARP Inhibitor Olaparib Enables Radiosensitization of a Radiation-Resistant Prostate Cancer Model
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چکیده
منابع مشابه
investigating the feasibility of a proposed model for geometric design of deployable arch structures
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Methods The TO-PARP trial has a multistage phase II design consisting of a non-randomised component with response as the primary endpoint followed by a randomised component with overall survival as the primary endpoint. Non-randomised component : This part of the trial design allows rapid progression to a randomised comparison if there is evidence of a high response rate (50% or more) in unsele...
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15 صفحه اولJF-305, a pancreatic cancer cell line is highly sensitive to the PARP inhibitor olaparib
Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA nick sensor involved in the base excision repair (BER) pathway. Olaparib, a PARP inhibitor, has demonstrated antitumor activity in homologous recombination (HR)-deficient cancers. To extend this specific therapy to other types of carcinomas, a panel of 11 different cancer cells were screened in the present study. JF-305, a pancreatic cancer cell l...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2016
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2016.06.2120